Exercise hemodynamic effects of captopril.

Controlled trial of captopril in chronic heart failure: a rest and exercise hemodynamic study.

Hemodynamic and volume changes associated with captopril.

The effects of captopril on bemodynamic, rolmne, and neurohumoral indices were inrestigated in 33 patients with essential hypertension or renal arterial disease. Changes associated with treatment were studied under two conditions: immediately (V4 to 1 boar) after administration of the drug, or after 5 to 7 days of therapy. Blood pressure (BP) reduction in both conditions was due to a reduction ...

Antagonism of the acute hemodynamic effects of captopril in decompensated congestive heart failure by aspirin administration.

The concomitant use of angiotensin-converting enzyme inhibitors and aspirin may cause pharmacological antagonism. Hence we examined the effect of aspirin on the neurohormonal function and hemodynamic response to captopril in heart failure patients. Between April 1999 and August 2000, 40 patients were randomized into four equal groups: 1) captopril, 2) aspirin, 3) captopril-aspirin: captopril wa...

Metabolic, hemodynamic, and cardiac effects of captopril in young, spontaneously hypertensive rats.

Spontaneously hypertensive rats (SHR) demonstrate elevated blood pressure, cardiac hypertrophy, glucose intolerance, and insulin resistance compared with age-matched Wistar-Kyoto rats (WKY). We investigated concurrent effects of captopril on blood pressure, cardiac mass, myocardial enzyme activities, glucose tolerance, and insulin action in young male SHR. At 10 weeks of age, SHR were randomize...

Hemodynamic and antihypertensive effects of captopril, an orally active angiotensin converting enzyme inhibitor.

Captopril inhibits angiotensin II formation and bradykinin degradation in vivo. Eleven patients with essential hypertension (EH) and four patients with renovascular hypertension (RVH) were treated with captopril for periods ranging from 3 days to 12 months. All patients had a diastolic blood pressure (DBP) over 95 mm Hg after receiving a placebo for 3 days. Captopril given in ascending doses (1...